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Bruker BioScope Resolve AFM

Bruker BioScope Resolve AFM

Bruker BioScope Resolve AFM

BioAFM with highest resolution and most complete biomechanics

Bruker NanoSurfaces

 

 

Bruker’s BioScope Resolve BioAFM features the highest resolution atomic force microscopy imaging and most complete cell mechanics capabilities available for use with an inverted optical microscope. BioScope Resolve incorporates Bruker’s exclusive PeakForce Tapping technology to enable researchers to achieve the highest resolution biological imaging and piconewton-level force measurements and spectroscopy at every pixel. The system’s real-time synchronization of optical and atomic force microscopy data opens the door to previously inaccessible data, including physical structure, biochemical interactions, and mechanical properties, to provide unique insights into life sciences research.

 

Features:

Accurate, repeatable and complete cell mechanics data

Ultimate force control - PeakForce QNM has become the preferred mode for nanomechanical mapping. With new algorithms, it delivers highest resolution property maps at pN forces on live cells.

Widest range of ramp rates - At the core of quantitative nanomechanical maps are force-distance curves. Beyond characterising elastic response, ramp rate dependent data provides insight into viscoelasticity or into molecular interactions times at the single molecule level.

Covering the whole spectrum - Brulker's new RampScriptTM allows the user to build, control and record complex nanomechanical measurements for use in protein pulling, ligand-receptor interaction, cell relaxation and viscoelastic probing.

Fast Tapping on Living Cells - BioScope Resolve is the only BioAFM that enables fast scanning while simultaneously providing the large piezo scanner range necessary for capturing the dynamic behaviour of living cells in real time (XYZ = 100µm x 100µm x 15µm). The Fast Tapping capabilities of Resolve are truly a step forward in condcuting high-resolution AFM studies at timescales relevant to cellular proceeses.

 

For further information please contact us or download the datasheet.

 

PeakForce QNM topography image (left) and corresponding modulus image (right) of living MDCK cells. Cell structures corresponding to actin fibers show higher modulus (lighter) while cell surface features, believed to be microvilli, appear softer (darker) than the cell membrane itself. (1 kHz PeakForce QNM, 32 μm image).

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BioScope Resolve brochure                                          Read more on Bruker's website