New UV-Vis Spectrophotometer
Edinburgh Instruments has recently launched the high performance DS5 Dual Beam UV-Vis Spectrophotometer that measures absorption and transmission as a function of wavelength.
Designed and manufactured in the UK, the DS5 provides a modern, user-friendly and accurate UV-Vis spectrophotometer for a wide range of sample types and measurements.
Utilising a dual lamp and Czerny-Turner configuation monochromator, the DS5 features a compact, reliable and high throughput optical system which ensures impressive spectral performance. Additional benefits include stray light, baseline flatness, wavelength and photometric accuracy and reproducibility.Read More
Coherent Axon Compact Femtosecond Laser
Coherent has introduced the Axon family, a completely new suite of compact femotsecond lasers, designed from inception to deliver lower cost, reduced complexity and smaller footprint. Axon addresses demanding applications such as multiphoton microscopy (MPE), nanoprocessing, semiconductor metrology and THz spectroscopy. Axon is a fixed wavelength, compact (212mm x 312mm x 62mm), air-cooled laser. The first two models have output wavelengths of 920nm and 1064nm, with other wavelength versions expected soon. All Axon lasers feature the same form, fit and function, including 1W of average power with integrated, software-controlled GVD pre-compensation. To further simplify adaption of this laser, its output matches the existing femtosecond laser oscillators: short (<150fs) pulse width, a clean temporal profile and 80MHz pule repetition rate.
A major application of the Axon lasers is multiphoton microscopy. The 920nm laser is designed for GFP and related imaging probes, and Ca2+ indicators such as GCAMP. The 1064nm version matches well with red shifted Ca2+ indicators and red fluorescent proteins. Although MPE delivers inherent 3D images, deep penetration and high cell viablity, market adoption lags well behind confocal microscopy because the cost and size of available femtosecond lasers and the challenges of integrating them with a microscope. The combination of the optional integrated fast modulation and small laser head allows for direct attachment of Axon to a microscope scan head, potentially negating the need for an optical table.
Other applications for Axon include two-photon polymerisation, material nanoprocessing and semicondcutor and thin film metrology. The 1064nm model is also an excellent tool for supercontinuum generation thanks to its high fidelity femtosecond pulse quality.Read More
New PowerMax-Pro OEM Sensors
The PowerMax-Pro OEM laser power sensor with large active area, fast response, and high power capacity offer advantages over the semiconductor detectors commonly used for continuous inline monitoring applications. In addition to unassembled OEM detectors, Coherent offers fully assembled and calibrated “developer’s kit” sensors. This configuration can be used as a fast, low power sensor or by engineers to facilitate the design process.
The PowerMax-Pro OEM utilises Coherent’s patented transverse thermoelectric detector technology which combines a fast response speed with the broadband wavelength coverage, large detection area, dynamic range and laser damage resistance of a thermopile. This enables PowerMax-Pro to offer a higher performance and cost competitive, alternative to photodiodes, which commonly have small active areas and require optical attenuation and complex pre-amplification for onboard power measurement in precision materials processing systems.
Typical applications include aesthetic medical systems, precision micromachining systems used in microelectronics manufacturing (e.g. via drilling), solar cell fabrication, medical device production, and various tasks in converting/packaging.
New Femtosecond Amplifier
The new Monaco HE is an ultrafast amplifier that delivers higher pulse energy over a wider operating range. Specifically, it delivers pulse energies of up to 2mJ at repetition rates as high as 10kHz (at 1030nm) and provides up to 25W of average power at repetition rates as high as 25kHz, with independent adjustment of both the pulse repetition rate and the pulse energy. Because the pulse width can be software varied from <250fs to >10ps, this amplifier can service demanding scientific applications, as well as advanced materials processing tasks. In addition, the Monaco HE measures a compact 70.4 x 46.5 x 29.6cm, making it attractive for both end users and OEM's.
Until now, laser amplifier users had to choose between Ti:S systems that offer high pulse energy at low (1-10kHz) repetition rates, or ytterbium-based amplifiers that typically feature high repetition rates but lower pulse energy. By combining several innovations in ytterbium laser technology, the all-new Monaco HE delivers both high pulse energy and high pulse repetition rates, and thus provides access to the performance gap that previously existed between these two technologies. Just as important, the Monaco HE was designed and manufactured from inception using rigorous HALT/HASS protocols. These techniques are essential to delivering exceptional levels of reliability and operational stability in lasers and amplifiers, and are a cornertsone of Coherent's Industrial Revolution in Ultrafast Science.
The combination of high pulse energy and high repetition rate makes the Monaco HE well-suited for spectroscopy applications such as multidimensional spectroscopy and time-resolved spectroscopy, which it can be also be used to pump tunable optical parametric devices such as an OPA or OPCPA. The high peak power also enables efficient THz genertaion, providing easier access to this spectral region of increasing interest and research activity.Read More
Webinar : AFM Application in Single Molecule Studies
Thursday 4 July 2019
Auckland (NZST) : 5:30pm
Brisbane, Sydney, Canberra, Melbourne, Hobart (AEST) : 3:30pm
Adelaide (ACST) : 3pm
Perth (AWDT) : 1:30pm
Cells can sense, adapt to, and even remodel their extracellular microenvironment. The interplay between the cell and its environment involves multiplex signalling networks, in which many molecules duly implement their own functions. Using traditional biochemical techniques, the molecular function can only be investigated based on the averaged activities of a large amount of molecules; while single molecule techniques can provide more detailed information by resolving the structure and interaction of each individual molecule. For example, AFM (Atomic Force Microscopy) can reveal how many different conformations of Aβ amyloid fibrils exist at a specific condition, and how each conformation interacts with the monomeric protein. The monomer-monomer or monomer-fibril interaction variation can be monitored in-situ while the environmental conditions (e.g., pH and ionic strength) are changed.
On the other hand, force has been utilised by nature to drive protein conformational changes, therefore modulate its stability and functionality. Such mechanical mechanisms are widely involved in physiological events at cellular level. To understand these mechanisms at the molecular level, it is necessary to manipulate single bio-molecules and resolve sub-pN forces. Thanks to recent improvements in spatial, temporal, and force resolutions, AFM and optical tweezers are capable to address the above requests. Now the single molecule stretching and rupture events can be directly resolved with sub-nm distance and pN force resolutions. The mechanical stability of processive motors (e.g., kinesin and myosin) have been widely studied with optical tweezers. Subtle forces have been applied on ion-binding proteins and antigen-antibody complexes to understand the mechanical effect on the binding affinity.
In this webinar Bruker share the recent technological developments in this field and some examples in molecular applications of AFM and optical tweezers.Read More